effect of ionizing radiation on development process of t-cell population lymphocytes in chernobyl children

نویسندگان

m.r. sheikh sajjadieh department of clinical immunology & allergology, national medical academy for post graduate education, kiev, ukraine

l.v. kuznetsova department of clinical immunology & allergology, national medical academy for post graduate education, kiev, ukraine

v.b. bojenko ukrainian clinical investigation of radiation protection public, kiev, ukraine

n.b. gydz ukrainian clinical investigation of radiation protection public, kiev, ukraine

چکیده

background: the aim of preliminary study was determined development process status of t-cell population lymphocytes in ukrainian children after 22 years from chernobyl accident for next feasibility study. material and method: 150 participants aged 6 to 16 years are included in three groups: group i (n=65), 30 to 60 km from center accident at zone 3th, group ii (n=65) 60 to 90 km from same location at zone 4th and control group (n=20) from kiev, 100 km from same location. peripheral blood leukocytes from buffy coats were analyzed for t-lymphocytes population such as t-lymphocytes (cd3), t-helper (cd4) and t-cytotoxic (cd8) by roseting method using erythrocytes that conjugated with monoclonal antibody against cd3, cd4, and cd8 receptors then cd4/cd8 ratio were calculated. results: percentage of cd3 and cd4 in groups ii and i decreased significantly in compared to control group at p<0.001. percent of cd8 decreased significantly in group i compared to control group at p <0.001. cd4/ cd8 ratio decreased significantly in-group i comparison to control group at p=0.02. leucocytes count in groups ii and i have not changed significantly in comparison to control group (p=0.09,p=0.4) but in group ii, it was significantly different in comparison to group i at p <0.008. conclusion: our data show that after 2 decade of chernobyl accident, ionizing radiation may have affected the developmental processes of t-cell population. iran. j. radiat. res., 2009 7 (3): 127-133

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عنوان ژورنال:
iranian journal of radiation research

جلد ۷، شماره ۳، صفحات ۱۲۷-۱۳۳

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